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Rheumatoid Arthritis is commonly used as the prototype for inflammatory arthritis. The incidence rate is approximately 3%, with two to three times greater occurrence in women.
RA primarily occurs in the synovial tissue where phagocytosis produces enzymes within the joint. The enzymes break down collagen causing edema, proliferation of the synovial membrane, and ultimately pannus formation. Pannus destroys cartilage and erodes the bone and the consequence is loss of articular surfaces and joint motion. Further, tendon and ligament elasticity and contractile power are lost.
It is not just a single disease and it can affect people at any stage of life. Arthritis is a complex disorder that comprises more than 100 distinct conditions. Arthritis literally means joint inflammation which can affect joints in any part of the body. Joints are places where two bones meet. Manifestations of arthritis may vary, usually reflecting the stage and severity of the disease. Classic symptoms include joint pain, swelling, warmth, erythema and lack of function.